Orthopaedic engineering
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MEC8049: Orthopaedic engineering
Part 2: Dr Piergiorgio Gentile (STB, mezzanine floor, M2a)
Dr Ana Ferreira Duarte (STB, second floor 2.21)
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Part 2 Date Room Lecturer Topic 9th March at 1 pm MERZ L302 AFD Introduction 10th March at 3 pm MERZ L302 AFD 1. Biological strategies for improving osseointegration
16th March at 1 pm MERZ L302 PG 2. Biological surface functionalisation to improve biological
features 17th March at 3 pm MERZ L302 PG 2. Biological surface coating technologies: Layer-by-Layer
23rd March at 1 pm MERZ L302 AFD 3. Additive manufacturing: bioprinting
24th March at 3 pm MERZ L302 AFD & PG 3. Additive manufacturing: 3D printing
27th April at 1 pm MERZ L302 AFD 4. Cell therapy 28th April at 3pm MERZ L302 PG 4. Bone models for orthopaedics
04th May at 1 pm MERZ L302 AFD 5. Biological Complications and Their Management 05th May at 3 pm MERZ L302 PG 6. An overview on the orthopaedic standards
11th -12th May Revision
week
AFD & PG Consultancy hours for the Report 2
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1. Biological strategies for improving osseointegration (AFD)
Roach (2007) J Mater Sci Mater Med 18:1263 Gittens et al. (2011) Biomaterials 32:3395
Part 2
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2. Biological surface functionalisation to improve biological features (PG)
Richardson et al. (2015) Science 348, aaa2491
Part 2
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3. Additive manufacturing: bioprinting & 3D printing (AFD & PG)
Part 2
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4. Cell therapy & bone models for orthopaedics (AFD & PG)
Part 2
Measurable data to predict the risks
Enables3R’s
• Tissue and organ regeneration
• Understanding/analysis and treatment of diseases (e.g. cancer, osteoarthritis, osteoporosis, etc.)
• Drug discovery and evaluation
https://www.frontiersin.org/articles/10.3389/fbioe.2017.00040/full
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5. Biological complications and their management (AFD)
Part 2
Figure 1. (a–c) X-ray of a 36 year-old male patient few days following curettage of a low-grade chondrosarcoma of the left proximal tibia. (b and c) Follow-up radiographs 7 and 13 months following index surgery showing integration but no resorption of the artificial bone graft substitute. https://www.nature.com/articles/s41598-017-02048-w
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6. An overview on the orthopaedic standards (PG)
Part 2
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Assessment (%)
Written examination Report 1 (Part 1) Report 2 (Part 2)
90 min 4 long questions, 2 from each half of the course (Part 1 & 2)
Report 1 is due in week 30
Report 2 is due in week 37 (11 May*)
*These dates are to be confirmed
Assessment
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Projects
Solve a device issues for a particular musculoskeletal
application (eg. THR, cancer drug screening, fixation
plates and screws, etc)
1. Antibacterial coatings on metals
2. Antibacterial coatings on polymers
3. Osseointegration of polymeric implants
4. Osseointegration of porous metallic implants
5. Bioprinting vs 3D printing on metals or polymers
6. Bioprinting of in vitro bone models
7. Issues and troubleshooting on bioprinting for
orthopaedics
8. More are coming!
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Report Structure
Structure (limit 20 pages)
Abstract (200 words)
Introduction
Motivation & background
Literature Review
Methods*
Discussion and Analysis
Conclusion
Marking criteria
Capability (70%)
✓ Quality of background (30%)
✓ Description and justification of selected process and/or manufacturing route to solve specific implant issue (20%)
✓ Commercial viability, lifecycle, regulations and standards (20%)
Organisation
Relevance and prioritisation
Deployment of evidence
Making logically reasoned argument
Basic requirements – Presentation (30%)
Task specification
Style and format
Sources and references
Plain English
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Assessment Table 1. GENERIC CRITERIA USED TO ASSESS AN ENGINEERING REPORT
BASIC REQUIREMENTS – “PRESENTATION” CAPABILITY – “TECHNICAL CONTENT”
Task Specification – does the Report cover (completely) what was
asked for and does it do so at an appropriate (eg as specified or
suggested) length?
Organisation – does the Report have clearly stated objectives
(appropriate to the Task Specification) and lead logically to a
statement of conclusions for each one?
Style and format for engineering Reports
– does it conform to the normal English-speaking world
professional engineering conventions? (see separate Checklist at end)
Relevance and prioritisation – is there a balanced choice of content
appropriate to the stated Report objectives and focussed on
reaching conclusions to these?
Sources – identified for all data, information, opinions, etc with
appropriate citation from Report text as well as adequate
unambiguous referencing?
Deployment of evidence – is this chosen and presented appropriately
and impartially to the issues under consideration?
Plain English – is the presentation always clearly understandable to
technically-literate (but not necessarily specialist) readers? Eg, are
specialist terminology or acronyms defined?
Making a logically reasoned argument – is the evidence systematically
evaluated to arrive at every outcome (opinion, assumption, deduction
or conclusion) by well-argued reasoning?
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(Some) Literature
Biological strategies for improving osseointegration https://www.sciencedirect.com/science/article/pii/ S0169409X15000484
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC439 0115/
Biological surface coating/functionalisation to improve biological features (i.e. LbL) https://www.sciencedirect.com/science/article/pii/ S0142961213001154
https://www.sciencedirect.com/science/article/pii/ S0167779909002352
Additive manufacturing: 3D printing and bioprinting https://www.sciencedirect.com/science/article/pii/ S1005030218301798
In vitro models and cell therapy https://www.ncbi.nlm.nih.gov/pmc/articles/PMC591 0611/
Biological Complications and Their Management https://link.springer.com/article/10.1007/s11914- 018-0441-0
An overview on the orthopaedic standards (according ASTM International)
How to find good literature???
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1.Scientific databases Scopus, Web of Science, Pubmed, Scholar Google, … http://www.ncl.ac.uk/library/resources/ )
2. Use appropriate keywords (eg. don’t be too broad or narrow in the research)
3. Give a look on the abstract. Is it pertinent to your project topic? YES: go on in the reading of the paper NO: move on the next one
4. Create your “personal” library that collects all the pertinent papers for your report (eg. in Excel?)
(Some) Literature